New research reveals that people who stop using blockbuster GLP-1 drugs like Wegovy and Mounjaro can put back on lost weight far faster than those who stop traditional lifestyle programs.
Findings released in a major health publication shows that while obese individuals often shed substantial amounts of their body weight while using the jabs, the mass returns at an estimated rate of 0.8 kg per month after stopping.
"Individuals purchasing these medications must be informed of the potential of fast weight regain when the therapy concludes," warns researcher Dr. Susan Jebb.
This pace of recovery implies a return to pre-treatment mass within about a year and a half.
Analyzing Therapies
The research, which examined 37 of studies involving over 9,000 of participants, contrasted the results of the injectable medications with other pills.
Researchers note that individuals who shed pounds through diet and exercise generally have a slower creep back—approximately 100 grams monthly—post-intervention.
Understanding the Fast Rebound
Experts suggest the mechanism of the injections explains the heightened weight return.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 concentrations far above than the body's typical production may cause the system to produce less of its endogenous hormone, and could reduce sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication leads to appetite is uncontrolled, making excessive eating much more probable."
An Ongoing Condition?
The NHS advise the injections for individuals with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts say that, considering the high risk of weight regain, the treatment might need to be life-long.
This perspective is echoed by drug manufacturers, who state that the findings "underscore the long-term character of excess weight," similar to managing conditions like hypertension.
User Testimonies
Users who have come off the medication describe a intense resurgence of appetite.
"It was like something that goes on and you're instantly starving," said one woman.
The struggle is exacerbated if individuals have not established lasting dietary or behavioural modifications during therapy.
Widespread Use
Figures indicate that a significant number of adults in the UK have tried these injections in the last 12 months, with interest remaining high.
- Use is higher among women compared to males.
- The middle-aged demographic shows the highest usage rates.
- Many access the medications through private healthcare rather than the NHS.
In conclusion, experts caution that while these medications are potent tools for shedding pounds, they are not a permanent solution and lasting health benefits hinges on combined behavioural changes.
